Inspissated Bile Syndrome. In one case series it accounted for around 8% of the infants with a surgical cause for their jaundice, with an estimated incidence of 1 in 175,000 live births [1]. Inspissated bile syndrome (ibs) is defined as the obstruction of the extrahepatic duct by a bile plug, sludge without bile duct malformation, congenital chemical defects of the bile, or hepatocellular lesions.
[PDF] Neonatal Cholestasis Due to Biliary Sludge Review
Inspissated bile syndrome (ibs) is a rare condition in which thick intraluminal bile, including bile plugs, sludge, or stones, blocks the extrahepatic bile ducts in an infant. This and other causes of ibs such as blood transfusion, parental nutrition in preterm infants, diuretic medication, and bowel dysfunction could initiate ibs [7]. Neonatal obstructive hyperbilirubinemia associated with biliary ductal dilation can occur in the context of inspissated bile syndrome, an uncommon condition characterized by biliary sludge [9].
[PDF] Neonatal Cholestasis Due to Biliary Sludge Review
1 hdn may cause diffuse hepatocellular. Inspissated bile syndrome inspissated bile syndrome is an uncommon cause of jaundice in neonates. A 'billable code' is detailed enough to be used to specify a medical diagnosis. Inspissated bile syndrome was diagnosed when sludge was found in the gall bladder and choledochal duct sonographically and hyperbilirubinemia (50 μmol/l), elevation of liver enzymes (gammaglutamatetransferase 447 u/l, alcalic phosphatase 373 u/l) and feeding intolerance developed.